Dr Annalisa Manca sitting on a chair

Why Chronic Pain Affects High-Functioning Women

October 08, 2026•4 min read

The women I see in my practice rarely arrive saying they've given up. Most of them are still working and still running a household, and often they're the one everyone else calls. They come because their body has started refusing, and nobody has been able to tell them why.

Chronic pain is more common in women, and it follows a recognisable pattern in women who have spent years holding everything together. Long-term pressure keeps the nervous system on alert. A brain that stays on alert for long enough becomes more likely to produce pain, exhaustion and other symptoms, even when the body itself shows no damage.

What holding everything together looks like

You might recognise some of this:

  • you remember everyone's appointments, birthdays and needs, often before your own

  • you keep going when you're tired, and rest only once everything is done

  • you feel responsible for how other people feel

  • you're praised for being capable, reliable and strong

  • asking for help feels harder than doing it yourself

  • your own needs come last, so often that you've stopped noticing

If most of these sound familiar, you're in good company. These are usually the women other people lean on.

Why the nervous system pays the price

Your brain's first job is to keep you safe. When life asks a lot of you for a long time, it responds by staying ready: alert, scanning, prepared for the next thing. For a while that readiness helps you cope. Over years, it becomes the setting your system runs on.

A brain that lives on alert gets better at detecting threat, and pain is one of the ways it signals threat. So the alarm becomes more sensitive. Sensations that once would have passed unnoticed start to hurt, sleep stops restoring you, and exhaustion settles in. Researchers call part of this process central sensitisation. It's closely linked to neuroplastic pain, where the brain keeps producing pain after the body has healed.

The brain is where this pattern is learned and held. The body is where you feel it.

Where these patterns come from

Very few women decide to live this way. Many learned it early. If being good, helpful or low-maintenance was what kept things calm at home, a child's nervous system takes that lesson seriously, and carries it into adult life.

The world then tends to reward it. Women still carry most of the unpaid work of caring, at home and often at work, and they're praised for doing it without complaint. Being endlessly available becomes part of who you are, and part of what others expect from you.

None of this is a personal failing. These patterns made sense. They helped you cope, and very often they helped everyone around you cope too. They also came at a cost, and the body is where that cost tends to show up.

When the body finally stops

For many women, pain becomes the first reason to stop that nobody can argue with, including themselves. Exhaustion wasn't enough, and neither was grief or overwhelm. Pain is.

Then comes the search for answers. Tests come back normal, or show something nobody can connect to how much it hurts. Some women are told it's stress, as though that explained anything. Some leave with a diagnosis and a leaflet about pacing, then go back to the same life that wore them down. Research has repeatedly found that women's pain is more likely than men's to be underestimated, so many have had to fight simply to be believed.

The diagnosis names what is happening to her body. It rarely asks what her life has been asking of it.

Why getting better can feel complicated

This is the part of recovery that almost nobody talks about. When your pain has been the one thing that let you stop, getting better can mean going back to carrying everything again. Part of you may want relief and fear it at the same time. That isn't a sign you don't want to recover. It's a sign your nervous system is still protecting you.

Understanding this is often what lets recovery start to move. It's the focus of my free guide, Why It Happened to You.

What helps

Change usually comes from small, repeated signals of safety, the kind that slowly teach your brain it no longer needs to stay on alert:

  • Understanding the pattern. When your symptoms make sense, there's less fear feeding them.

  • Resting before you're empty. Short, regular rest is easier for your system to accept than collapse. There's more on this in why you feel worse when you finally rest.

  • Noticing the old patterns as they happen. Catch the automatic yes, or the urge to do it perfectly. You're not trying to fix anything overnight, just to see it.

  • Being believed. Support from someone who takes your experience seriously is a safety signal in its own right.

If your symptoms are new, changing or worrying you, please see your doctor first, so other causes can be properly ruled out.

Where to start

If you recognise yourself here, my free guide goes further: why chronic pain and exhaustion arrive in women who kept going, why getting well can feel frightening, and one short practice to begin with.
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Send me the free guide

Dr Annalisa Manca

Dr Annalisa Manca

Dr Annalisa Manca is a psychotherapist and chronic pain coach, and the author of The Safety Signal. This article is for general information and doesn't replace medical advice.

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